Histocompatibility

Check Accredited by the American Society for Histocompatibility and Immunogenetics (ASHI), the College of American Pathologists (CAP), and the United Network for Organ Sharing (UNOS), ClinImmune Labs and its well-qualified technical staff are committed to providing the highest quality histocompatibility testing services for research studies as well as clinical transplantation and transfusion programs in Colorado, across the U.S. and abroad.

Testing available for:

  • Immunotherapy, including vaccine development
  • Clinical Transplantation- solid organ and hematopoietic stem cell
  • Platelet Transfusion support
  • Genetic  HLA Disease Association

Clinically Approved Assays:

  • HLA-A, B, C, DRB, DQ, DPB1 loci
    • Low to high resolution testing for HLA-A, B, C, DRB1,DRB3/4/5, DQB1, DPB
    • High resolution testing for HLA-DPB1
    • Intermediate resolution testing for DQA1 and DPA1
  • HLA Antibody Detection
    • PRA=Panel Reactive Antibody, including HLA Specificity Analysis: Luminex
    • Titration/Quantitation studies for pre-transplant immunotherapy protocols
    • Crossmatching for transplant compatibility: Flow Cytometry
    • Platelet support panels to assess allo-reactive HLA antibodies and HLA-A,B typing for selection of matched platelets
  • KIR genotyping and phenotyping

Services Provided:

  • Initial consultations provided for test selection, cost effectiveness, sample and turn-around time requirements
  • Immunogenetics testing (e.g. HLA-B*57:01 screening test to determine susceptibility to abacavir hypersensitivity syndrome and HLA-B27 which may assist in the diagnosis of ankylosing spondylitis, juvenile rheumatoid arthritis, and Reiter's syndrome)
  • Transplant Immunology Teleconferences  presented at ClinImmune (contact Pat at Pat.Supon@ucdenver.edu to be added to the emailed announcement list)
  • Customized requisitions and clear, concise reports; electronic data transfer
  • Additional test interpretation consults upon request
  • Donor search strategy support
  • Analysis of HLA allele frequency
  • HLA epitope analysis as part of population studies